Siluron® 2000

The premium silicone oil with the customized extensional viscosity

Siluron® 2000

Syringe G-80740 Siluron® 2000, 10 ml, sterile

  • High resistance to emulsification
  • Short injection time
  • Exceptional long-term tolerance
  • Excellent chemical purity

Innovative molecular design for a new generation of silicone oils

Due to their special molecular structure, the Siluron® Xtra and Siluron® 2000 have, compared to the standard silicone oils, in vitro a high emulsification resistance. Both innovative silicone oils consist of a mixture of ultra-long molecular chains having a viscosity in the range of 2,500,000 mPas and of short molecular chains with a viscosity in the range of 1,000 mPas.

Thanks to this special molecular design, Siluron® Xtra and Siluron® 2000 can modify their viscous
properties depending on the permanent high shear forces, such as they appear in the eye due to its constant movement: the greater the applied shear force is, the more viscous behaves the silicone oil, i.e. the more resistant it is to emulsification. By contrast, the viscosity of the conventional oils decreases continuously as a result of permanently acting external forces, which causes a higher tendency for emulsification.

The new generation of silicone oils – Siluron® 2000 und Siluron® Xtra – is characterized by its special
property of a significantly higher emulsification resistance.
This is based on an intelligent mixture of different long chains of molecules and the resulting dynamic viscosity. The good injectability in cases of small incisions is a further advantage of innovative silicone oils.

Literature: Chan YK., Ng CO., Knox PC., Garvey MJ., Williams RL., Wong D.:
Emulsification of silicone oil and eye movements; Invest Ophthalmol Vis Sci. 2011; 52: 9721-9727

Use

Siluron® 2000 is used with a long-term tamponade after operative treatment of severe
retinal detachment, particularly for:

  • Retinal detachments with giant tears
  • Retinal detachments with proliferative vitreoretinopathy (PVR)
  • Retinal detachments in cases of proliferative diabetic retinopathy (PDR)
  • Traumatic retinal detachment

Physicochemical properties of Siluron® oils

Property Siluron® 1000 Siluron® 5000 Siluron® 2000 Siluron® XTRA
Density [g/cm³] 25 °C 0,97 0,97 0,97 0,97
Viscosity [mPas] 25 °C 900 – 1200 4800 – 5500 2000 – 2400 4100 – 4800
Solubility in water non miscible non miscible non miscible non miscible
Composition 100 % Poly-
dimethylsiloxan
(PDMS)
100 % Poly-
dimethylsiloxan
(PDMS)
95 % Siluron®
1000 + 5 % PDMS
(2,5 Mio. mPas)
90 % Siluron®
1000 + 10 % PDMS
(2,5 Mio. mPas)
Elasticity (Je0) [Pas] 2 x 10-5 1 x 10-5 6,5 x 10-5 1,4 x 10-3
Shear viscosity
(bei 8,37 s-1, 37 °C) [mPas]
931 4303 1800 4377
Volatile components
(200 °C, 24 h) [%]
≤ 0,2 % ≤ 0,2 % ≤ 0,2 % ≤ 0,2 %

Source: Caramoy A., Hagedorn N., Fauser S., Kugler W., Gross T., Kirchhof B.: Development of emulsification-resistant silicone oils:
can we go beyond 2000 mPas silicone oil? Invest Ophthalmol Vis Sci. 2011; 52: 5432-5436

Comparison of emulsification rate

Source: Caramoy A., Hagedorn N., Fauser S., Kugler W., Gross T., Kirchhof B.: Development of emulsification-resistant silicone oils: can we go beyond 2000 mPas silicone oil? Invest Ophthalmol Vis Sci 2011; 52: 5432-5436

Comparison of emulsification resistance

Source: Wong et. al

Comparison of injection time

5.5 bar injection pressure, 20 gauge injection cannula

Source: Williams RL ., Day MJ ., Garvey MJ., Morphis G ., Irigoyen C ., Wong D., Stappler T.: Injectability of silicone oil-based tamponade agents. Br J Ophthalmol. 2011; 95: 273-276